Associate Director/ Director, Medicinal Chemistry

Associate Director/ Director, Medicinal Chemistry

Website Atavistik Bio

Position Summary

We are looking for a talented and self-driven individual with a strong background in medicinal chemistry to join Atavistik’s Discovery group. This individual will assume a leading role in shaping the growing medicinal chemistry organization, drive innovation internally and externally, and ensure project goals are delivered on time. The individual will play a central role in collaborating with both internal and CRO researchers in enabling new projects for drug discovery at Atavistik. Successful candidates will be able to thrive in a fast-paced environment and be passionate about science. This individual will report directly to the Head of Chemistry.

Key Responsibilities

  • Creative thinker to design and implement medicinal chemistry and drug discovery strategies for novel small molecule projects from Hit finding to IND-enabling studies
  • Leadership: Provide scientific and strategic leadership to drive progression of drug discovery projects from screening to development candidate. Lead multi-disciplinary teams, utilizing cross-functional data to drive drug discovery strategies in a matrix organization environment.
  • Coordinate and manage external partners effectively to ensure project goals are achieved. Pro-actively solve problems and address synthetic challenges
  • Collaborate with cross-functional partners in biochemistry, biology, molecular pharmacology, etc. to drive programs to key go/no go decisions
  • Proactively communicate strategic objectives to team members and determine project scope and budgets.
  • Contribute to intellectual property strategies and contribute to the drafting of patent applications
  • Present scientific results internally (or externally) in a concise and effective manner, including scientific challenges, and strategy development to address any issues
  • Build and foster an inclusive work environment including managing direct reports

Required Qualifications

  • Doctoral degree (PhD) or equivalent in synthetic organic chemistry or medicinal chemistry
    >10 years of experience in a pharmaceutical industry/biotech in the field of small molecule drug design with a proven record of leading projects towards clinical candidates, managing a chemistry team including CRO chemists
  • Advanced knowledge and expertise of modern synthetic methods, advanced principles of medicinal chemistry and protein-ligand interactions, including structure-based drug discovery (SBDD), and experience in partnering with computational chemists, pharmacologists, DMPK, toxicologists to drive program deliverables
  • Track record of innovation and impact on programs as evidenced by patent inventorship and authorship of peer-reviewed publications
  • Deep understanding of the patent process and the ability to draft technical patent applications independently
  • Excellent oral and written communication skills, ability to present results in a concise and clear way to audiences of diverse scientific and business backgrounds
  • Highly organized, self-motivated, and desire to succeed in a fast-paced organization

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