Position Summary

We are looking for a multitalented and self-driven individual with a strong background in biochemical and biophysical assay development. As a startup company, this is a great opportunity to collaboratively build and contribute to the drugging strategy. The ideal candidate will have a strong background in assay development, an in-depth understanding of biochemistry and biophysics, and experience with small molecule drug discovery programs. The individual will play a central role in close coordination with internal scientists and collaboratively enable new projects for drug discovery.

Key Responsibilities:

• Independently design, develop biochemical and biophysical assays for target enablement and hit finding
• Characterize proteins, troubleshoot experiments, optimize assays suitable for SAR development
• Conduct enzyme mechanism of action studies to guide screening and drug discovery approaches
• Organize, manage, and analyze experimental data
• Collaborate with diverse project teams internally to champion lead discovery and progression of small molecules
• Analyze and present results at cross-functional team

Required Qualifications:

• MS with 8-10 years or BS with 10-12 years or Ph.D. with 0-4 years of experience in small molecule drug discovery industry
• Extensive experience in biochemical and binding assay development with a variety of readout formats (Fluorescence, FRET, LC-MS, FP, etc.)
• Hands-on knowledge of biophysical methods such as SPR, DSF, SEC-MALS, ITC, etc. is required
• Experience in assay optimization, steady state kinetics, mechanism of action studies, compound profiling, and screening
• Experience in protein purification using AKTA systems
• Excellent communication and collaborative skills to work on the project team with biologists, chemists, and metabolism scientists
• Highly organized, self-motivated with the desire to succeed

For immediate consideration please share your CV complete with a full list of publications.