Senior Scientist II, Chemistry

Senior Scientist II, Chemistry

Website TRIANA Biomedicines, Inc.


As an integral part of TRIANA Biomedicine’s discovery team, this candidate will be a medicinal chemistry leader, driving programs from hit generation to candidate selection.  The candidate will be responsible for co-leading project teams, designing compounds, devising chemistry strategy, and managing of external resources.  The successful candidate is expected to demonstrate strong communication skills, work effectively in a dynamic and high energy environment, form strong cross-functional relationships, and exhibit creative problem-solving skills. 


  • Strong understanding of all aspects of compound optimization including synthetic chemistry, structure-based drug design, ligand-based drug design, pharmacokinetics, pharmacology, and toxicology.
  • Ability to consistently identify landmark improvements in SAR.
  • Strong working knowledge of in silico design toolsExperience in managing external CROs to enable efficient execution of synthesis.
  • Demonstrates strategic thinking and devise innovative approaches to support drug discovery activities and accomplish project objectives. Experience in several small molecule modalities/MOAs would be a plus.
  • Expected to collaborate with legal teams to establish intellectual property strategy and lead the preparation of patent documents, peer reviewed scientific publications, and regulatory documents, as appropriate.
  • Excellent understanding of the drug discovery process and experience in advancing small molecules from hit identification to high quality candidates is highly desirable.
  • Experience in program team leadership or as a lieutenant is highly desirable.
  • A clear and effective communicator to present project strategy and progress to internal and external collaborators and stakeholders.
  • Experience managing timelines and external chemistry resources to drive projects toward key decision criteria with an emphasis on high quality outcomes is desirable.
  • Demonstrated leadership in drug discovery with track record of significant contributions to innovative drug discovery projects, exemplified by a consistent record of patent inventorship and publications.
  • Develops and maintains effective working relationships with people across cultures and orientation, encouraging collaboration across teams, organizations, and geographies.


PhD in organic chemistry, medicinal chemistry, or related discipline with 4+ years of drug discovery in biotechnology or pharmaceutical industry or BSc/MSc in organic chemistry, medicinal chemistry, or related discipline with 10+ years of drug discovery in biotechnology or pharmaceutical industry. Exceptional candidates that fall outside these guidelines will also be strongly considered.

About TRIANA Biomedicines:

TRIANA Biomedicines is a greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high- resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate.


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