Principal Scientist/Associate Director, Chemistry

Principal Scientist/Associate Director, Chemistry

Website Triana BioMedicines Triana BioMedicines

About TRIANA Biomedicines:

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate.

Role Responsibilities:

As an integral part of TRIANA Biomedicine’s discovery team, this candidate will be a medicinal chemistry leader, driving programs from hit generation to candidate selection.  The individual will be responsible for co-leading project teams, designing compounds, devising chemistry strategy, and the managing of external resources.  The successful candidate is expected to demonstrate solid communication skills, perform well in a collaborative and dedicated work environment, form cross-functional relationships, and exhibit creative problem-solving skills. 


·       Clear understanding of all aspects of compound optimization including synthetic chemistry, structure-based drug design, ligand-based drug design, pharmacokinetics, pharmacology, and toxicology.

·       Ability to consistently identify landmark improvements in SAR.

·       Solid working knowledge of silico design tools.

·       Experience in managing external CROs to enable efficient execution of synthesis.

·       Demonstrated strategic thinking and devised innovative approaches to support drug discovery activities and accomplish project objectives. Experience in several small molecule modalities/MOAs would be a plus.

·       Expected to collaborate with legal teams to establish intellectual property strategy and lead the preparation of patent documents, peer reviewed scientific publications, and regulatory documents, as appropriate.

·       Excellent understanding of the drug discovery process and experience in advancing small molecules from hit identification to high quality candidates is highly desirable.

·       Experience in program team leadership or as a scientific discipline lead.

·       A clear and effective communicator able to present project strategy and progress to internal and external collaborators and stakeholders.

·       Experience managing timelines and external chemistry resources to deliver on time projects toward key decision criteria with an emphasis on high quality outcomes.

·       Demonstrated leadership in drug discovery with track record of significant contributions to innovative drug discovery projects, exemplified by a consistent record of patent inventorship and publications.

·       Develops and maintains effective working relationships with people across cultures and orientation, fostering collaboration across teams, organizations, and geographies.


PhD in organic chemistry, medicinal chemistry, or related discipline with 8+ years of drug discovery in biotechnology or pharmaceutical industry or BSc/MSc in organic chemistry, medicinal chemistry, or related discipline with 12+ years of drug discovery in biotechnology or pharmaceutical industry.


We welcome applications from uniquely skilled individuals whose qualifications may not fully fit the criteria outlined above.

Our Culture:

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.

Our Values:

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission.

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Thank you for your interest in TRIANA!

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